As someone who dealed a bit with print design in the past, I consider CMYK colors the easiest color system for humen to understand and manipulate. It’s very similar to what we used as children, when mixing watercolors for our drawings. It makes perfect sense, more than HSL and definately more than RGB. I understand that most of us are so accustomed to using RGB that can’t realise that, but try to think for a moment: Which color system would make more sense to you if you had no idea and no experience at all with any of them?
UPDATE: New version
First of all, happy Valentine’s day for yersterday. 🙂 This is the second part of my “Using CSS3 today” series. This article discusses current RGBA browser support and ways to use RGBA backgrounds in non-supporting browsers. Bonus gift: A PHP script of mine that creates fallback 1-pixel images on the fly that allow you to easily utilize RGBA backgrounds in any browser that can support png transparency. In addition, the images created are forced to be cached by the client and they are saved on the server’s hard drive for higher performance.